Image Fusion

Table of Contents

Contrast Clearance Analysis

General Information

Contrast Clearance Analysis* visualizes the accumulation of a contrast agent against its rate of clearance. The method works by acquiring two MRI series – one at 5 minutes and another at approx. 75 minutes after injection of a standard dose of contrast agent – and subtracting the first series from the second, resulting in a high-resolution color-coded map. Use Image Fusion to fuse and compare the two MRI image sets.

* Developed at Sheba Medical Center with technology provided by Brainlab.



Accumulation of the contrast agent (slow clearance)


Clearance of the contrast agent (fast clearance)


The Contrast Clearance Analysis calculation requires two 3D MRI volumes. For these:

  • Both sequences must be acquired using the equivalent scan protocol

  • The first sequence must be taken approx. 5 minutes after contrast agent injection (using e.g., Gd/Gadolinium)

  • The second sequence must be taken 60-105 minutes after contrast agent injection

Article No. 60917-40EN

Date of publication: 2017-10-23